Table 4.
Blood pressure and heart rate responses compared between amiloride and placebo trials matched for effort
| Placebo |
Amiloride |
RMANOVA |
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|---|---|---|---|---|---|---|---|---|---|---|
| n | BL | T50 | T100 | BL | T50 | T100 | Time | Drug | Int. | |
| HRmean, beats/min | 10 | 60 ± 6 | 72 ± 8 | 77 ± 8 | 62 ± 5 | 73 ± 6 | 78 ± 8 |
F = 47.70 ηP2 = 0.84 *P < 0.01 |
F = 1.12 ηP2 = 0.11 P = 0.31 |
F = 0.39 ηP2 = 0.04 P = 0.68 |
| MAPmean, mmHg | 10 | 83 ± 7 | 92 ± 8 | 94 ± 8 | 83 ± 7 | 95 ± 11 | 97 ± 13 |
F = 42.49 ηP2 = 0.82 *P < 0.01 |
F = 0.56 ηP2 = 0.05 P = 0.47 |
F = 1.32 ηP2 = 0.12 P = 0.27 |
| SBPmean, mmHg | 10 | 112 ± 9 | 123 ± 13 | 127 ± 14 | 114 ± 10 | 127 ± 16 | 133 ± 21 |
F = 26.46 ηP2 = 0.74 *P < 0.01 |
F = 1.69 ηP2 = 0.15 P = 0.22 |
F = 1.11 ηP2 = 0.11 P = 0.35 |
| DBPmean, mmHg | 10 | 71 ± 7 | 78 ± 7 | 80 ± 7 | 71 ± 8 | 80 ± 9 | 82 ± 11 |
F = 52.50 ηP2 = 0.85 *P < 0.01 |
F = 0.22 ηP2 = 0.02 P = 0.64 |
F = 1.70 ηP2 = 0.16 P = 0.20 |
| HRpeak, beats/min | 10 | 60 ± 6 | 85 ± 8 | 62 ± 5 | 87 ± 8 |
F = 169.77 ηP2 = 0.95 *P < 0.01 |
F = 1.77 ηP2 = 0.16 P = 0.21 |
F = 0.01 ηP2 < 0.01 P = 0.90 |
||
| MAPpeak, mmHg | 10 | 83 ± 7 | 102 ± 12 | 83 ± 7 | 106 ± 13 |
F = 70.25 ηP2 = 0.88 *P < 0.01 |
F = 0.85 ηP2 = 0.08 P = 0.38 |
F = 4.19 ηP2 = 0.31 P = 0.07 |
||
| SBPpeak, mmHg | 10 | 112 ± 9 | 135 ± 19 | 114 ± 10 | 144 ± 21 |
F = 44.59 ηP2 = 0.83 *P < 0.01 |
F = 2.53 ηP2 = 0.22 P = 0.14 |
F = 3.03 ηP2 = 0.25 P = 0.11 |
||
| DBPpeak, mmHg | 10 | 71 ± 7 | 87 ± 10 | 71 ± 8 | 90 ± 10 |
F = 88.29 ηP2 = 0.90 *P < 0.01 |
F = 0.31 ηP2 = 0.03 P = 0.59 |
F = 5.73 ηP2 = 0.38 *P = 0.04 |
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| BPI, mmHg·s/1,000 | 10 | 25.9 ± 13.2 | 49.4 ± 25.9 | 29.5 ± 13.2 | 56.5 ± 26.2 |
F = 28.0 ηP2 = 0.75 *P < 0.01 |
F = 8.68 ηP2 = 0.49 *P = 0.01 |
F = 5.22 ηP2 = 0.36 *P = 0.04 |
||
| BPInorm, mmHg/kg | 10 | 8.1 ± 4.1 | 8.4 ± 4.3 | 8.2 ± 4.1 | 8.6 ± 4.3 |
F = 10.5 ηP2 = 0.54 *P = 0.01 |
F < 0.01 ηP2 < 01 P = 0.95 |
F = 0.188 ηP2 = 0.02 P = 0.67 |
||
| Lactate, mmol/L | 10 | 1.4 ± 1.0 | 2.0 ± 1.0 | 1.5 ± 0.8 | 2.1 ± 1.3 |
F = 15.35 ηP2 = 0.63 *P < 0.01 |
F = 0.05 ηP2 < 0.01 P = 0.82 |
F < 0.01 ηP2 < 0.01 P = 0.96 |
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Data are means ± SD for placebo and amiloride; n, number of participants. BL, baseline; BPI, blood pressure index; BPInorm, BPI normalized to the time-tension index; DBP, diastolic blood pressure; HR, heart rate; MAP, mean arterial pressure; ηp2, partial η squared; SBP, systolic blood pressure; T50, 50% of total exercise time within each trial; T100, 100% of total exercise time within each trial; TM50, time matched for 50% of total exercise time in the placebo trial; TM100, time matched for 100% of the total exercise time in the placebo trial. *Statistically significant P value.