Table 1.
Choroid plexus blood flow in different species by a variety of methods
| Species | Sex | Age | Anesthesia | Detection Method | 4th Ventricle, mL/g/min | Lateral Ventricle, mL/g/min | References |
|---|---|---|---|---|---|---|---|
| Rabbit | M | Adult | Pentobarbital | Octanol bubble | 2.86 | (136) | |
| Cat | M and F | Adult | Chloralose | Microspheres | 3.01 ± 0.32 | (276) | |
| Cat | Adult | Pentobarbital | Microspheres | 2.26 ± 0.28 | (277) | ||
| Cat | Adult? | Pentobarbital | Microspheres | 2.40 ± 0.56 | (278) | ||
| Rat | Adult | Pentobarbital | Diffusible indicator | 1.34 ± 0.09 | 0.85 ± 0.05 | (279) | |
| Rabbit | Adult | Ketamine, xylazine | Diffusible indicator | 1.03 ± 0.03 | 0.82 ± 0.06 | (279) | |
| Dog | Adult | Pentobarbital | Hydrogen electrode | 0.73 ± 0.12 | (280) | ||
| Rabbit | Adult | Pentobarbital | Microspheres | 2.78 ± 0.68 | (281) | ||
| Sheep | F | Adult | Pentobarbital | Microspheres | 6.01 ± 0.44* | (282) | |
| Sheep | F | Adult | Pentobarbital | Microspheres | 3.81 ± 0.44; 7.25 ± 0.75 | (283) | |
| Pig | Newborn | Halothane | Microspheres | 2.81 ± 0.25 | (284) | ||
| Rabbit (NZW) | Adult? | Chloralose | Microspheres | 3.85 ± 0.73 | (285) | ||
| Dog | Adult? | Pentobarbital | Microspheres | 2.87 ± 0.26 | (285) | ||
| Rabbit (NZW) | Adult? | Chloralose | Microspheres | 3.24 ± 0.4; 3.30 ± 0.35 | (275) | ||
| Rabbit (NZW) | Adult? | None | Microspheres | 3.65 ± 0.54; 3.53 ± 0.59 | (275) | ||
| Rabbit (NZW) | Adult | Chloralose | Microspheres | 3.69 ± 0.26 | (286) | ||
| Rabbit (NZW) | Adult | Chloralose | Microspheres | 4.07 ± 0.82; 3.98 ± 0.60 | (274) | ||
| Rat (Long Evans) | M | Adult | None | Autoradiography | 4.25 ± 0.35 | 5.25 ± 0.39 | (287) |
| Rat (SD) | M | Adult | None | Microspheres | 1.56 ± 0.05 | 0.83 ± 0.01 | (288)† |
| Rat | Adult | Pentobarbital | Indicator fractionation N-isopropyl-p-[125I]iodoamphetamine | 4.12 ± 0.08 | 3.30 ± 0.07 | (9) | |
| Rat (WKY) | Adult | Urethane | Indicator fractionation | 2.4 ± 0.08 | (289) | ||
| Rat (SHR) | Adult | Urethane | Indicator fractionation | 2.82 ± 0.21 | (289) |
Most studies were carried out in anesthetized animals under well-controlled physiological conditions (normal Po2, Pco2). In most studies, plexus blood flow was only measured in the lateral ventricular plexus. When it was also measured in 4th ventricular plexus it was generally higher than the lateral plexus. *Increased by 27% at Pco2 58 mmHg; much greater increase in cerebral blood flow at this Pco2 (199%). †Hypercapnia (Pco2 62 mmHg) did not increase choroid plexus blood flow. In animals anesthetized with chloralose, anesthesia was induced with chloroform or thiopentone. F, female; M, male; ns, not significant; NZW, New Zealand White; SD, Sprague Dawley; SHR, spontaneously hypertensive rat; WKY, Wistar Kyoto.