Figure 1.

The expression of PDZK1 and ABCG2 in HCC is mediated by the stimulation of soluble uric acid. (a, b) The mRNA expression of PDZK1 and ABCG2 were significantly increased in hepatocellular cells were exposed to different concentrations of soluble uric acid (2.5, 5, 10, and 20 mg/dl) for 24 hours. (c, d) The mRNA expression of PDZK1 and ABCG2 after treated with 10 mg/dl soluble uric acid for 4, 8, 16, 32, 48, and 64 hours, data represent mean ± SD. ^∗P < 0.05 compare with negative control.