FIG. 1.

Blocking of IL-10 does not restore lymphocyte proliferation in response to acapsular C. neoformans 67 cultured in the presence of polysaccharide. PBMC and C. neoformans (Cn) were cultured in the presence or absence of capsular polysaccharide (10 μg/ml) and anti-IL-10 or control antibody (1 μg/ml). Lymphocyte proliferation was assessed 7 days later by [³H]TdR incorporation. ∗, P < 0.05 by analysis of variance. NS, not significantly different compared to stimulated PBMC. †, P < 0.05 compared to PBMC plus C. neoformans. NS₁, not significantly different from PBMC plus C. neoformans plus CPS. The experiment was repeated three times with similar results.