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Inhibition of phagocytosis abrogates uptake and lymphocyte proliferation of acapsular C. neoformans 67. PBMC were stimulated with C. neoformans in the presence of various concentrations of lidocaine. Coverslips were examined for the percentage of cells that had bound or internalized C. neoformans (Crypto) (A), and [3H]TdR incorporation was assessed (B). ∗, P < 0.01 compared to 0 M lidocaine by analysis of variance. The experiment was repeated three times with similar results.
