Table 3.
KEGG metabolic pathway enrichment analysis of NR-autism spectrum disorder.
| Pathway | Enrichment | P-value | Count | Gene |
|---|---|---|---|---|
| Proteoglycans in cancer | 128.9493902 | 4.75E–15 | 7 | ACTB AKT1 CASP3 ESR1 MAPK1 MAPK3 SRC |
| Thyroid hormone signaling pathway | 187.2582645 | 1.01E–13 | 6 | ACTB AKT1 ESR1 MAPK1 MAPK3 SRC |
| Prolactin signaling pathway | 269.7410714 | 3.22E–12 | 5 | AKT1 ESR1 MAPK1 MAPK3 SRC |
| Endocrine resistance | 192.6721939 | 1.80E–11 | 5 | AKT1 ESR1 MAPK1 MAPK3 SRC |
| Platelet activation | 152.2731855 | 5.95E–11 | 5 | ACTB AKT1 MAPK1 MAPK3 SRC |
| Apoptosis | 138.8373162 | 9.51E–11 | 5 | ACTB AKT1 CASP3 MAPK1 MAPK3 |
| Yersinia infection | 137.8239051 | 9.87E–11 | 5 | ACTB AKT1 MAPK1 MAPK3 SRC |
| Estrogen signaling pathway | 136.8251812 | 1.02E–10 | 5 | AKT1 ESR1 MAPK1 MAPK3 SRC |
| Hepatitis B | 116.554784 | 2.30E–10 | 5 | AKT1 CASP3 MAPK1 MAPK3 SRC |
| Influenza A | 110.4203216 | 3.03E–10 | 5 | ACTB AKT1 CASP3 MAPK1 MAPK3 |
| Tuberculosis | 104.8993056 | 3.92E–10 | 5 | AKT1 CASP3 MAPK1 MAPK3 SRC |
| Neutrophil extracellular trap formation | 99.37828947 | 5.15E–10 | 5 | ACTB AKT1 MAPK1 MAPK3 SRC |
| Kaposi sarcoma-associated herpesvirus infection | 97.32925258 | 5.72E–10 | 5 | AKT1 CASP3 MAPK1 MAPK3 SRC |
| Pathogenic Escherichia coli infection | 95.84708122 | 6.18E–10 | 5 | ACTB CASP3 MAPK1 MAPK3 SRC |
| Focal adhesion | 93.93967662 | 6.83E–10 | 5 | ACTB AKT1 MAPK1 MAPK3 SRC |
| Rap1 signaling pathway | 89.91369048 | 8.52E–10 | 5 | ACTB AKT1 MAPK1 MAPK3 SRC |
| Chemical carcinogenesis - receptor activation | 89.06544811 | 8.93E–10 | 5 | AKT1 ESR1 MAPK1 MAPK3 SRC |
| VEGF signaling pathway | 256.0254237 | 9.13E–10 | 4 | AKT1 MAPK1 MAPK3 SRC |
| Lipid and atherosclerosis | 87.82267442 | 9.59E–10 | 5 | AKT1 CASP3 MAPK1 MAPK3 SRC |
KEGG = Kyoto Encyclopedia of Genes and Genomes, NR = Naringenin.