TABLE 2.

Prechallenge safety—clinical signs following vaccination with NOBL SC-54 or various vaccine candidate strains

Strain or group	Timea	Mortality (%)b	Morbidity score (%)b	Diarrhea score (%)b	% of pigs culture positive (vaccine strains)	ADG (kg)	Mean temp (°C)c
Nonvaccinated, challenged	Pre	0	0	1.0			39.4
	Post	0	0	1.2	0	0.73	40.2*
Nonvaccinated, nonchallenged	Pre	0	0	0			39.6
	Post	0	0	0	0	0.69	40.3*
NOBL SC-54	Pre	0	0	0			39.8
	Post	0	0	4.2	0	0.64	40.4*
χ3246	Pre	0	0	0			NT
	Post	20.0	23.3	46.2	80.0	−0.03	NT
χ3781	Pre	0	0	8.3			39.4
	Post	0	0	1.8	0	0.65	40.9**
χ3923	Pre	0	0	3.1			39.7
	Post	0	0	1.2	0	0.65	40.6*
χ4186	Pre	0	0	1.0			39.5
	Post	0	0	2.4	0	0.66	41.2**
χ4497	Pre	0	0	1.0			39.4
	Post	0	0	0	0	0.70	40.0*
χ4522	Pre	0	4.1	5.2			39.8
	Post	0	0	1.2	0	0.69	40.4*
χ4814	Pre	0	0	4.2			39.7
	Post	0	0	3.0	0	0.70	40.2*

^aPre, mean for the 4 days prior to vaccination; post, mean for the 1-week period postvaccination except for temperatures. 

^bMaximum possible severity is 100%. 

^c“Pre” values are the mean temperatures for the 4 days before vaccination. “Post” values are the mean maximum temperatures for the post vaccination period. NT, not tested. * and **, values in the same column with different superscripts are significantly different (P < 0.05).