Table 1.
Families and types of gliomas with relevant genetic parameters (82).
| Tumor Family | Tumor type | Altered molecular profiles |
|---|---|---|
| Adult-type diffuse gliomas | Astrocytoma, IDH-mutant | IDH1, IDH2, ATRX, TP53, CDKN2A/B |
| Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted | IDH1, IDH2, 1p/19q, TERT promoter, CIC, FUBP1, NOTCH1 | |
| Glioblastoma, IDH-wildtype | IDH-wildtype, TERT promoter, chromosomes 7/10, EGFR | |
| Pediatric type diffuse low-grade gliomas | Diffuse astrocytoma, MYB- or MYBL1-altered | MYB, MYBL1 |
| Angiocentric glioma | MYB | |
| Polymorphous low-grade neuroepithelial tumor of the young | BRAF, FGFR family | |
| Diffuse low-grade glioma, MAPK pathway-altered | FGFR1, BRAF | |
| Pediatric type diffuse low-grade gliomas | Diffuse midline glioma, H3 K27-altered | H3 K27, TP53, ACVR1, PDGFRA, EGFR, EZHIP |
| Diffuse hemispheric glioma, H3 G34-mutant | H3 G34, TP53, ATRX | |
| Diffuse pediatric-type high-grade glioma, H3-wildtype, and IDH-wildtype | IDH-wildtype, H3-wildtype, PDGFRA, MYCN, EGFR (methylome) | |
| Infant-type hemispheric glioma | NTRK family, ALK, ROS, MET | |
| Circumscribed astrocytic gliomas | Pilocytic astrocytoma | KIAA1549-BRAF, BRAF, NF1 |
| High-grade astrocytoma with piloid features | BRAF, NF1, ATRX, CDKN2A/B (methylome) | |
| Pleomorphic xanthoastrocytoma | BRAF, CDKN2A/B | |
| Subependymal giant cell astrocytoma | TSC1, TSC2 | |
| Chordoid glioma | PRKCA | |
| Astroblastoma, MN1-altered | MN1 |