Table 2.
Table summarizing the details of recent relevant studies on lnRNAs as diagnostic and/or prognostic biomarkers in gliomas.
| Year and Reference | lnRNA | Study Type | Patients and Samples | Correlation |
|---|---|---|---|---|
| 2022 [101] | LINC00565 LINC00641 |
Diagnostic Prognostic |
GBM patients (35) Healthy individuals (15) |
Sens: 97%, Spec: 100%, and AUC: 0.994 Sens: 100%, Spec: 93.3%, and AUC: 0.995 Negative OS |
| 2022 [102] | MALAT1 SNGH16 |
Prognostic | Medulloblastoma (41) Epilepsy specimens (5) |
Negative Negative |
| 2022 [103] | LINC01087 | Prognostic | Glioma tissue (80) Adjacent tissue (80) |
Negative |
| 2022 [104] | DLGAP1-AS1 | Prognostic | TCGA and CGGA | Negative |
| 2022 [105] | LINC00265 CIRBP-AS1 GDNF-AS1 ZBTB20-AS4 |
Prognostic | TCGA (504) CGGA (513) |
Negative |
| 2021 [106] | ANRIL SOX9 |
Diagnostic Prognostic |
Glioma (142) Healthy volunteers (120) |
Sens: 81.62% and Spec: 90.83% Negative OS |
| 2021 [107] | SBF2-AS1 | Prognostic | LGG (524 from TCGA, 431 from CGGA) | Negative |
| 2021 [108] | BLACAT1 | Prognostic | Glioma tissue (137) Adjacent tissue (137) |
Negative |
| 2021 [109] | LINC00355 | Prognostic | Glioma tissue (121) Adjacent tissue (121) |
Negative |
| 2021 [110] | CYTOR MIR155HG LINC00641 AC120036.4 PWAR6 |
Prognostic | CGGA (89 LGG and 92 GBM) TCGA (405 LGG and 136 GBM) Patient samples (38 LGG and 53 GBM) |
1-year AUC: 0.72 3-year AUC: 0.92 5-year AUC: 0.90 |
| 2020 [111] | FTX | Prognostic | Glioma tissue (187) Adjacent tissue (187) |
Negative |
| 2020 [112] | ZNF667-AS1 | Diagnostic Prognostic |
Glioma tissue (155) Adjacent tissue (155) |
Sens: 68.22%, Spec: 84.57%, AUC: 0.8541 Negative OS |
| 2020 [113] | ELF3-AS1 | Diagnostic Prognostic |
Glioma tissue (182) Adjacent tissue (182) |
AUC: 0.8073 Negative OS |
| 2019 [114] | LINC00319 | Prognostic | Glioma tissue (72) Adjacent tissue (72) |
Negative |
| 2019 [115] | PEG10 | Prognostic | Glioma patients (147) | Negative |
| 2019 [116] | LINC01503 | Prognostic | Glioma patients (133) | Negative |
| 2019 [117] | PXN-AS1-L | Prognostic | Glioma tissue (177) Adjacent tissue (177) |
Negative |
| 2018 [118] | PlncRNA-1 | Prognostic | Glioma tissue (104) Adjacent tissue (104) |
Negative |
| 2018 [119] | AFAP1-AS1 | Prognostic | Glioma tissue (52) Non-tumor controls (5) |
Negative |
| 2018 [120] | LINC00961 | Prognostic | Glioma tissue (151) Adjacent tissue (151) |
Positive |
| 2018 [121] | MRCCAT1 | Prognostic | Glioma tissue (103) Normal brain tissue (21) |
Negative |
| 2018 [122] | MEG3 | Prognostic | Glioma tissue (79) Adjacent tissue (79) |
Positive |
| 2017 [123] | UCA1 | Prognostic | Glioma tissue (64) Normal brain tissue (10) |
Negative |
| 2017 [124] | SNHG1 | Prognostic | Glioma (78) Normal brain tissue (12) |
Negative |
| 2017 [125] | PVT1 | Prognostic | Glioma (80) Normal brain tissue (10) |
Negative |
| 2016 [126] | AGAP2-AS1 TPT1-AS1 LINC01198 MIR155HG |
Prognostic | Anaplastic glioma from GSE16011 (80) | Negative Positive Negative Negative |
| 2016 [127] | AB073614 | Prognostic | Glioma (65) Normal brain tissue (13) |
Negative |
| 2016 [128] | ZEB1-AS1 | Prognosis | Glioma (82) Normal brain tissue from cerebral trauma/epilepsy (13) |
Negative |
| 2015 [129] | MALAT1 | Prognosis | Glioma tissue (118) Adjacent tissue (15) |
Negative |
| 2015 [130] |
BC002811 XLOC_010967 NR_002809 |
Prognosis | Astrocytoma (90) | Positive Positive Negative |
TCGA, The Cancer Genome Atlas; CGGA, Chinese Glioma Gene Atlas; OS, overall survival; Sens, sensitivity; Spec, specificity; LGG, low-grade glioma.