Table 1.

Description of vital status, sex, EDI score and age at onset of MS overall and according to MS phenotype.

	Overall (n = 34,169) n (%)	R-MS (n = 30,083) n (%)	PPMS (n = 4086) n (%)
Vital status as of 2016/01/01
Deceased	1849 (5.4%)	1311 (4.4%)	538 (13.2%)
Lost to follow-up	2350 (6.9%)	2054 (6.8%)	296 (7‧2%)
Alive	29,970 (87.7%)	26,718 (88.8%)	3252 (79.6%)
Sex
Men	9848 (28.8%)	8057 (26.8%)	1791 (43.8%)
Women	24,321 (71.2%)	22,026 (73.2%)	2295 (56.2%)
EDI
Median [percentiles 2.5; 97.5]	−0.6 [−5.6; 11.9]	−0.6 [−5.6; 11.8]	−0.6 [−5.5; 12.6]
Age at MS onset
Median [quartiles 1–3]	31.7 [24.9–40.0]	30.4 [24.3–38.1]	43.2 [35.0–50.3]
Year of onset of symptoms
[1960–1970]	655 (1.9%)	602 (2.0%)	53 (1.3%)
[1970–1980]	2114 (6.2%)	1926 (6.4%)	188 (4.6%)
[1980–1990]	5025 (14.7%)	4449 (14.8%)	576 (14.1%)
[1990–2000]	9917 (29.0%)	8628 (28.7%)	1289 (31.6%)
[2000–2010]	12,155 (35.6%)	10,545 (35.1%)	1610 (39.4%)
[2010–2015]	4303 (12.6%)	3933 (13.1%)	370 (9.1%)
Follow-up (years)
Median [quartiles 1–3]	15.7 [9.1–23.7]	15.8 [9.0–24.0]	15.2 [9.6–22.0]