Fig. 7.

HUMSCs-PRP-gel/nHA-PA66 significantly improved angiogenesis and morphological repair in bone defects at 6th week after surgery. A Relative area of new bone tissue in repair area. B Quantitative analysis of mean vessel density per mm². C Relative expression of PDGF-B, VEGFA and TGF-β1 mRNA in repair area. (3 randomized fields of view for each group. S: nHA-PA66 scaffold, NB: newly formed bone, F: fibrous and connective tissue, black arrows: microvessels, Scale bar = 100 μm. Data in mean ± SD, n = 5, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 versus Defect only group; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001 versus PRP-gel/nHA-PA66 group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus HUMSCs/nHA-PA66 group)