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. 2022 Nov 8;16:1047928. doi: 10.3389/fncel.2022.1047928

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Copyright © 2022 Smith, Park, Aalderink, Oldfield, Bergin, Mee, Faull and Dragunow.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglia from neurogenic ventricular/Hp tissue proliferate more than microglia from non-neurogenic cortical tissue. (A) PU.1 (green nuclei) and CD45 (red) double-positive microglia are present in glial cultures from cortical human brain tissue. (B) A greater number of microglia are present in ventricular/Hp cultures. (C,D) Immunocytochemical images of CD45 microglial cell surface marker (green) and Ki67 cell division marker (red) showing minimal proliferation of cortical microglia (C) and greater basal proliferation of ventricular/Hp microglia (D). Arrows indicate examples of Ki67-immunopositive microglia. Scale bar = 100 μm. (E) Quantification of the percentage of microglia cultured from cortical and ventricular/Hp regions that incorporate BrdU, showing a significantly greater percentage of dividing microglia in ventricular/Hp regions. Each data point indicates an individual case (n = 9). Cortex and SVZ/Hp samples from the same case are indicated by connecting lines. *indicates P value < 0.05.