Table 4.

EWCE analysis

Cell type	P-value	Fold change	SD from mean
Upweighted 10% (Pcor)
Glutamatergic	<1 × 10−10	2.89657	16.33697
GABAergic	0.00002	1.53571	4.95972
Non-neuronal: pericyte	0.39915	1.03437	0.20818
OPC	0.85648	0.87782	−1.04623
Microglia	0.98576	0.71634	−1.98875
Non-neuronal: VLMC	0.99380	0.57872	−2.21417
Endothelial cell	0.99947	0.57450	−2.78966
Astrocyte	0.99999	0.56620	−3.54350
Oligodendrocyte	1.00000	0.49659	−3.80922
Downweighted 10% (Pcor)
Astrocyte	<1 × 10−10	1.90801	7.21517
Non-neuronal: pericyte	0.29683	1.08003	0.49469
Non-neuronal: VLMC	0.33726	1.07361	0.37335
Microglia	0.46827	1.00395	0.02779
OPC	0.52067	0.98585	−0.12059
Endothelial cell	0.80142	0.86733	0.86733
GABAergic	0.84056	0.89153	−0.99208
Oligodendrocyte	0.99660	0.69286	−2.32499
Glutamatergic	0.99942	0.67336	−2.82282
Upweighted 10% (Group × NfL)
Non-neuronal: pericyte	0.03905	1.28857	1.85843
Microglia	0.06393	1.21547	1.59846
GABAergic	0.06428	1.16696	1.58190
Non-neuronal: VLMC	0.06945	1.26748	1.52874
Endothelial cell	0.24742	1.09724	0.65320
Oligodendrocyte	0.77574	0.90052	−0.78095
Glutamatergic	0.87605	0.87073	−1.13485
OPC	0.97856	0.79741	−1.84178
Astrocyte	0.99049	0.74715	−2.08759
Downweighted 10% (Group × NfL)
Glutamatergic	<1 × 10−10	2.832749	15.3434863
GABAergic	0.0001	1.4754347	4.27832
OPC	0.20687	1.0899718	0.7888829
Non-neuronal: VLMC	0.98562	0.6028899	−1.9850374
Endothelial cell	0.98776	0.6848202	−2.026815
Non-neuronal: pericyte	0.99747	0.5892623	−2.454821
Astrocyte	0.99978	0.6348877	−2.9696604
Oligodendrocyte	0.9999	0.6004525	−2.9841701
Microglia	0.99993	0.5594399	−3.0422093

Results for top 10% upweighted and downweighted genes using AHBA 2019 cell-specific gene classification.

OPC = oligodendrocyte precursor cells; Pcor = corrected significance; SD = standard deviation; VLMC = vascular leptomeningeal cells.