Figure 5.

Time from amyloid onset to impairment in ADNI. (A–D) Covariate adjusted survival curves indicating the probability of remaining unimpaired as a function of the time from A+ onset demonstrated that APOE-e4 carriage, being female and becoming A+ later in life were all associated with a shorter time from A+ onset to impairment onset (i.e. first CDR ≥1). Dotted lines in A–C represent 95% confidence intervals of the covariate adjusted survival functions. (E and F) Median time to impairment and the 10-year unimpaired rate following A+ onset were nonlinearly associated with the EAOA such that people who became A+ at an older age had greater risk of becoming impaired in a shorter time from A+ onset.