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. 2022 Oct 25;45(11):2729–2736. doi: 10.2337/dc22-0833

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© 2022 by the American Diabetes Association

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External replication and meta-analyses of significantly type 2 diabetes–associated IgG N-glycans and derived IgG N-glycosylation traits. Type 2 diabetes–specific IgG N-glycans were first selected in the EPIC-Potsdam study using MFPs and combined into a weighted IgG glycan score for type 2 diabetes risk (T2D-IgG-Score) in EPIC-Potsdam. Subsequently, the glycans, traits, and T2D-IgG-Score were validated in Finrisk (38 incident type 2 diabetes cases, 38 normoglycemia cases), JUPITER (13 incident type 2 diabetes cases, 52 normoglycemia cases), and TNT (51 incident type 2 diabetes cases, 153 normoglycemia cases).