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. 2022 Nov 8;13:1020918. doi: 10.3389/fphar.2022.1020918

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Copyright © 2022 Wei, Xie, Wei, Zhao, Ren, Feng and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory mechanisms of ferroptosis. The primary metabolism involved in ferroptosis can be roughly divided into three categories: iron metabolism, System Xc⁻/GSH/GPX4 pathway, and lipid peroxidation. Besides, the FSP1-CoQ₁₀-NAD(P)H pathway, which exists as an independent parallel system with GPX4 and GSH, inhibits phospholipid peroxidation and ferroptosis.