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. 2022 Nov 8;13:1033063. doi: 10.3389/fimmu.2022.1033063

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Copyright © 2022 He, Xie, Zhu, Zhuang, Huo, Yu, Guo, Shu, Xiong, Zhang, Lyu and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of diversity and composition of gut microbiota after eradication therapy. (A, B) Alpha diversity, representing the richness of microbiota, was significantly reduced immediately following eradication treatment (T2) and then gradually returned to baseline from T3 to T5. (C) Principal coordinate analysis (PCoA) based on Bray-Curtis distances revealed the overall microbiota composition differed between T2 and other time points. (D) Relative proportions of the top 10 bacterial phyla. (E) Relative proportions of the top 20 bacterial genera. A, probiotics group; B, placebo group; T1, pretreatment; T2, cessation of quadruple therapy; T3, 2 weeks after quadruple therapy; T4, 8 weeks after quadruple therapy; T5, 24 weeks after quadruple therapy; *, p<0.05; **, p<0.01, ***, p<0.001.