Table 5. Differences in INR, TB, and albumin levels between the first HV-TPE and multiple rounds of HV-TPE.

HV-TPE application	Once	More than twice	p-value
INR	5.65±5.52	3.93±2.37	1.0
TB (mg/dL)	8.6±6.78	11.95±5.29	0.38
Albumin (g/dL)	3.5±0.40	3.03±0.66	0.26

Values are presented as mean±standard deviation.

INR: international normalized ratio, TB: total bilirubin, HV-TPE: high-volume therapeutic plasma exchange.

p-values are calculated using the Mann–Whitney U-test (p-value<0.05).