Figure 6. DKK1-induced insulin resistance in mice which was related to the phosphorylation of JNK-AKT-FOXO1.

(A, B) The GTT (A) and ITT (B) analyses of mice with treatments of AAV-GFP-NC, AAV-OE-DKK1, or AAV-sh-DKK1 and HFD-fed 20 wk (n = 3). (C) Western blot analyses of phosphorylated JNK in AML12 cells under rDKK1 stimulation (N = 2). (D) Representative Western blot analyses of phosphorylated AKT and FOXO1 in AML12 cells under insulin and rDKK1 stimulation (N = 2). *P < 0.05, **P < 0.01, ***P < 0.001 as compared with the indicated controls by two-tailed t tests. All data are shown as the means ± SD.

Source data are available for this figure.