TABLE 2.
The changes of B cells in Children and elderly patients with sepsis.
Year/Authors | Subjects | Testing time | Main findings | References |
---|---|---|---|---|
Hotoura et al. (2011) | Full-term neonates; 25 sepsis patients 20, suspected infection 50, controls | Before treatment, 2 days after treatment, 48 h after treatment stops | The percentage of B cells in sepsis group and suspected group was higher than that in control group before and 2 days after treatment; the percentage of B cells in sepsis group remained unchanged before and after treatment | Hotoura et al. (2011) |
Hotoura et al. (2012) | Preterm neonates; 17 sepsis patients 25, suspected infection 40, controls | Before treatment, 2 days after treatment, 48 h after treatment stops | Before treatment, the percentage of B cells in sepsis group was higher than that in control group; the percentage of B cells in sepsis group after 48 h of treatment was lower than that before treatment | Hotoura et al. (2012) |
Pan et al. (2016) | 30 neonatal sepsis, numbers of controls: not provided | Not provided | The percentage of CD19+CD24hiCD38hi Breg cells and IL-10-producing Breg cells in sepsis patients was significantly higher than that in controls | Pan et al. (2016) |
Duan et al. (2020) | 16 neonatal sepsis 20, controls | Day 7, 14, and 21 after diagnosis | The number and frequency of B cells increased on day 7 and 14, and returned to normal on day 21, among which IL-10-producing transitional B cells are the main elevating B cell subset. | Duan et al. (2020) |
Remy et al. (2018) | 26 pediatric septic shock, 30 controls | Day 1–2, 3–5, and 7–9 after the onset | The absolute B-cell count in children with sepsis decreased slightly | Remy et al. (2018) |
Wang et al. (2017) | 58 elderly sepsis | Day 1, 3, and 7 after diagnosis | The percentage of CD19+CD24hiCD38hi Breg in the death group was lower than that in the survivor group | Wang et al. (2017) |