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. 2022 Nov 14;20:6403–6411. doi: 10.1016/j.csbj.2022.11.025

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Characterization of subtype-specific TFs and cellular interaction networks of CAFs. (A) Distribution plot of TFs using the SCENIC algorithm for the CAFs of ovarian cancer. (B) Heatmap of top10 activated subtype-specific TFs, the color indicates the relative expression level (Z-score) of TFs. (C) Heat map depicting the significant interactions among the identified major cell types, the color indicates the number of interactions between two specified TFs. (D) Overview of the selected ligand-receptor interactions. P-values (two-tailed permutation test) are indicated by circle size. The means of the average expression level of interacting molecule 1 in cluster 1 and interacting molecule 2 in cluster 2 are indicated by color.