TABLE 3.

Pathological features of the reported cases of inflammatory myofibroblastic tumor of the mesentery.

References #	Pathological features	Immunohistochemistry
Our case	Gross appearance: Large tannish glistening tumor mass in the center of the bowel loop, the other parts of the bowel were completely normal with attached pericolic fat that is also normal. Microscopy features: Myofibroblastic spindle cells in a loose myxoid stroma with minimal cellular atypia but no significant mitosis. Abundant chronic mononuclear inflammatory cells, mostly lymphocytes ± plasma cells, histiocytes and eosinophils. Lymphoid aggregations were scant.	+Ve: SMA. –Ve: ALK, CD117, DOG1, and Desmin.
(4)	Gross appearance: well-circumscribed, multinodular, grayish-white firm tumor with foci of hemorrhage, necrosis, and cystic change. Microscopy features: spindle cell tumor within a collagen-rich vascular stroma, with abundant inflammatory cells. The muscular layer of the bowel wall was invaded. Scattered giant cells and focal increased mitotic activities found.	+Ve: SMA and HHF-35. –Ve: CD34 and CD117.
(5)	Gross appearance: No infiltration to the adjacent structures. Microscopy features: spindle cells tumor with fascicular and haphazard growth patterns, mild to moderate pleomorphism and mitosis. Mixed stromal inflammatory cells, including plasmacytes, lymphocytes and few eosinophils.	+Ve: ALK-1, SMA and Desmin. –Ve: ND
(8)	Gross appearance: Firm, polypoid mass with whitish-gray whorled appearance. Microscopy features: Interlacing bundles of fibroblastic/myofibroblastic spindle cells with elongated and vacuolated nuclei, in a background of abundant blood vessels and a mixture of stromal inflammatory cells. Sant mitotic figures.	+Ve: ALK, Vimentin and SMA. –Ve: C-kit, Desmin, CD-34, EMA and CK.
(18)	Gross appearance: round mass. Microscopy features: the tumor composed of fusiform cells with eosinophilic cytoplasm and elongated or globular nuclei within a fibrotic stroma with vascular congestion and rare inflammatory cell elements of mononuclear WBCs and macrophages. Vascular congestion present. No aneuploidy or hypercellularity.	+Ve: Ki67. –Ve: BCL2, CD34, CD117, and PS100.
(19)	Gross appearance: huge (1,245 g), well-vascularized mass, almost completely calcified/necrotic. Microscopy features: No malignant tissues.	ND
(20)	Gross appearance: firm, homogenous, grayish white mass. Microscopy features: hypocellular smears and fascicles of spindle cells with band nuclei, arranged in a myxoid stroma with focal collagen deposition. Mixed inflammatory cells, including lymphocytes and plasma cells. Benign columnar cells were also noticed.	+Ve: ALK, SMA, and Desmin. –Ve: ND.
(21)	Gross appearance: A 25 cm friable mass at proximal jejunal mesentery, extending proximally to the ligament of Treitz. The texture of the mass was like lymphoma. Microscopy features: No jejunal submucosal invasion.	+Ve: SMA and Desmin. –Ve: ALK-1.
	Gross appearance: mesenteric tumor with associated bowel ischemia. Microscopy features: spindle and stellate cells tumor settled in a myxoid or hyaline stroma. Admixed with inflammatory cells.	+Ve: SMA and Desmin. –Ve: ALK-1.
(22)	Gross appearance: ND. Microscopy features: stellate/spindle cell tumor with epithelioid myofibroblastic cells within a mixed myxoid or compact fibrous stroma. Infrequent mitosis. Plasma cells, lymphocytes and neutrophils were seen.	+Ve: ALK-1, ALK-11, and RANBP-2. –Ve: ND
(23)	Gross appearance: Firm, grayish-white mass. Microscopy features: myofibroblasts spindle cells tumor with vascular myxoid stroma and lymphoplasmacytic inflammatory cells infiltrate. No mitosis, necrosis or pleomorphism found.	+Ve: Vimentin, SMA, and Desmin. –Ve: ALK-1.
	Gross appearance: large masses. Microscopy features: spindle cells tumor with inflammatory cells. No mitosis.
(24)	Gross appearance: ND. Microscopy features: well circumscribed mass composed of myofibroblastic, and fibroblastic spindle cells, arranged in fascicles and storiform patterns, and admixed with inflammatory cells including, lymphocytes, plasma cells, eosinophils, and histiocytes. The background had abundant blood vessels. Little mitotic activity. The tumor infiltrated the adjacent colon.	+Ve: ALK, SMA, and Desmin. –Ve: CD117, CD34, and S100.
(25)	Gross appearance: smooth encapsulated outer surface. Microscopy features: spindle cells tumor, without atypia, mixed inflammatory cells, including plasma cells, lymphocytes, and eosinophils. Central tumor necrotic debris. No tumor invasion into the colon or jejunum seen.	+Ve: Vimentin, Pankeratin, SMA, and Calponin. –Ve: ND
(26)	Gross appearance: circumscribed, nodular, solid, yellow-tan tumor with focal necrosis. Microscopy features: spindle cell tumor without atypia, arranged in myxoid background, along with admixed lymphocytes, plasma cells, and eosinophils. No mitotic figures. The small and large bowel were normal.	+Ve: ALK-1 and SMA. –Ve: Desmin.
(27)	Gross appearance: circumscribed, nodular, firm, grayish-white mass. Microscopy features: spindle cell tumor with fascicular growth pattern with collagenized stroma areas. Plasma cells and lymphocytes are found. No mitosis or extension to the adjacent small bowel.	+Ve: SMA and Vimentin. –Ve: CD34, CD117, S100, Desmin and Ki-67.
(28)	Gross appearance: dense, red (hyperemic) mass. The small bowel appeared inflamed but did not look ischemic or dilated. Microscopy features: spindle cell tumor with prominent eosinophils, laying in a myxoid stroma. It was invading the muscularis propria of the adjacent bowel.	+Ve: SMA, Desmin, and Cytokeratin. –Ve: CD117, b-Catenin, and ALK-1.
(29)	Gross appearance: solid grayish-yellow tumor with focal hemorrhage and myxomatous appearance. Microscopy features: fasciitis-like nodular pattern with myxoid stroma. Neoplastic ganglion-like cells. Erythrocytes extravasation and numerous inflammatory infiltrates, including neutrophils mostly, eosinophils, lymphocytes, and plasmacytes. Mitotic figures present. The tumor invaded the adventitia, muscular layer, and submucosa.	+Ve: ALK, CD30, Desmin, SMC, and RANBP2 gene. –Ve: CD117, S100, CD21.
(30)	Gross appearance: round, solid mass. Microscopy features: spindle cell tumor with a dense polymorphic infiltration of mononuclear inflammatory cells.	+Ve: Vimentin, SMA, and CD68. –Ve: CD34, CD117, and ALK-1.
(31)	Gross appearance: ND. Microscopy features: bland spindled/stellate cell tumor with mixed with inflammatory cells in a hyaline stroma. Few mitotic figures and minimal atypia.	+Ve: SMA and cyclooxygenase-2 (COX-2). –Ve: ALK.
(32)	Gross appearance: ND. Microscopy features: spindle cell tumor with mixed lymphocytes and plasma cells.	ND.
(33)	Gross appearance: well-demarcated, encapsulated hard white mass. Microscopy features: myofibroblastic cells with mixed foamy histiocytes and mild lymphoblastic infiltration. No neoplastic cells.	+Ve: Vimentin, SMA. –Ve: Desmin, S-100 protein, keratin, and CD34.
(34)	Gross appearance: ND. Microscopy features: interlacing fascicles of elongated spindle cells mixed with plasma cells, histiocytes, lymphocytes, and eosinophils.	ND.
(35)	Gross appearance: large, sticky mass. Microscopy features: spindle cells/Stellate cell tumor with eosinophilic neoplasm in a vascularized myxoid stroma. Abundant plasma cells and lymphocytes. Lymph nodes with reactive hyperplasia.	ND.
(36)	Gross appearance: Circumscribed tumor with focal infiltration into the adjacent fat. Microscopy features: spindle or epithelioid myofibroblastic tumor in a myxoid or sclerotic stroma with capillary vessels and mixed plasma cells and lymphocytes.	+Ve: ALK and SMA. –Ve: CD117 and cdk-4.
(37)	Gross appearance: solitary lobulated tumor with a whitish gray gritty sensation cut surface due to calcification. Microscopy features: fusiform, spindle cell tumor with a myxoid and hyalinized stroma. Increased stromal capillary vasculature and plasmacytes infiltration. Few mitotic figures. No atypical cells.	+Ve: SMA and Desmin. –Ve: ND.
	Gross appearance: rubbery, lobulated tumor with a whitish gray to yellow cut-surface. Microscopy features: bland spindle cell tumor, hyaline or myxoid stroma with lymphocytic infiltration. Few mitotic figures. No anaplasia.	+Ve: SMA and Desmin. –Ve: ND.
(38)	Gross appearance: irregular, lobulated, solid mass. Microscopy features: ND.	+Ve: ALK, CD3, and CD2. –Ve: ND.
(39)	Gross appearance: well-circumscribed, nodular mass with multi-lobulated, grayish-white cut section. No hemorrhage or necrosis. Microscopy features: spindle/stellate cell tumor with haphazard growth pattern, myxoid stroma with a small blood vessels and mixed inflammatory infiltrate, including plasma cells, lymphocytes, and lymphoid follicles.	+Ve: SMA. –Ve: ALK-1, CD34, CD117, DOG-1, S100, Ki-67.
(40)	Gross appearance: encapsulated, well-defined mass with central fibrotic components. Microscopy features: spindle cell tumor with inflammatory cells, including lymphocytes. The ileum, appendix, and lymph nodes were normal.	ND.
(41)	Gross appearance: ND. Microscopy features: spindle cell tumor with sclerotic, variably myxoid stroma, and mixed inflammatory cells, including plasma cells, lymphocytes, histiocytes, and neutrophils. The tumor infiltrated the nearby jejunal loops. No tumor deposits in mesenteric lymph nodes.	+Ve: ALK and Vimentin. –Ve: CD117.
(42)	Gross appearance: soft to firm, encapsulated, lobulated mass with a grayish-white glistening and myxoid cut-section appearance. Microscopy features: epithelioid to spindle cell tumor with eosinophilic cytoplasm, in a myxoid background with numerous blood vessels and mixed chronic inflammatory cells, including mature lymphocytes and plasma cells. Variable mitosis. No necrosis. Lymph nodes showed reactive lymphoid hyperplasia.	+Ve: ALK, Desmin, SMA, CD68, and CD30. –Ve: ND.
(43)	Gross appearance: circumscribed, rubbery, yellowish red tumor. Microscopy features: mixed spindle and epithelioid cells, in a myxoid stroma with mixed inflammatory cell infiltrates, including lymphocytes, plasma cells and neutrophils. Infrequent mitotic figures.	+Ve: ALK-1, SMA, CD30, and RANBP2. –Ve: cytokeratin, CK-4 and CD117.
(44)	Gross appearance: solid, non-cystic mass. Microscopy features: myofibroblastic spindled cell tumor with a fibromyxoid background, and mixture of chronic inflammatory infiltrates, including lymphocytes and plasma cells.	+Ve: SMA, ALK, and Desmin. –Ve: c-kit, S-100, and CD34.
(45)	Gross appearance: firm, multinodular, whorled cut section with myxoid appearance. Microscopy features: plump spindle cell tumor with myxoid or vascular growth patterns in a vascular stroma with mixed inflammatory cell infiltrates including, lymphocytes, histiocytes, plasma cells, and lymphoid aggregates. In addition, Stellate and ganglion-like polygonal cells were noticed.	+Ve: SMA, ALK-1, p53, Calponin, Desmin, and Ki67. –Ve: ND.
(46)	Gross appearance: ND. Microscopy features: the tumor invades the ascending colon and the terminal ileum.	ND
(47)	Gross appearance: well-circumscribed and firm mass. Gross-cut: it has a homogenous to a trabecular pattern. It appears myxoid, with no hemorrhage or necrosis, but there is a cyst. Microscopy appearance: the mass contains spindle cells and mononuclear inflammatory cells (lymphocytes, plasma cells). The appearance of spindle cell proliferation varies between interlacing fascicular pattern and storiform pattern. No mitosis.	ND.
(48)	Gross appearance: firm and circumscribed mass. Cut surface: it composed of yellow and white patches. Microscopic features: haphazard proliferation of fibroblast, lymphocytes, plasma cells, and eosinophils. It has a fusiform pattern and has infiltrated the muscularis propria of the small intestine. Few mitotic figures.	ND