Figure 5.

Optitype’s typing accuracy for HLA-A, -B and -C across 50 samples and across varying read lengths, DOCs and with/without artificially added chemical damage. The typing accuracy depends primarily on the DOC. Note that the downsampling, read cutting and addition of DNA damage was done after an extraction of HLA reads. This figure therefore represents a best case scenario, where assigning reads to the HLA region is as accurate for short reads as it is for the full length reads.