TABLE 1.
Toxicity of C. botulinum serotype A pure neurotoxin and neurotoxin complex injected into the stomach or intestinea
Time (h) | Survival (no. alive/total no.) after injection of:
|
|||
---|---|---|---|---|
Pure neurotoxin
|
HA+ complex
|
|||
Stomach | Intestine | Stomach | Intestine | |
24 | 0/10 | 1/10 | 5/10 | 7/10 |
48 | 0/10 | 6/10 | 9/10 | 9/10 |
72 | 0/10 | 9/10 | 9/10 | 9/10 |
96 | 0/10 | 9/10 | 9/10 | 9/10 |
Mice were injected with pure neurotoxin or HA+ complex. Samples were introduced directly into the stomach or directly into the intestine. No ligature was used to restrict neurotoxin movement. Animals were monitored, and the number of deaths was recorded at the end of each time period. Pure neurotoxin (25 ng/animal) and HA+ complex (equivalent to 25 ng of pure neurotoxin/animal) were used.