Table 2.
Cohort characteristics and their lesion analysis at baseline scan.
| Characteristic | IRL– | 1–3 IRL+ | ⩾4 IRL+ |
|---|---|---|---|
| No. (%) | 49 (53.8%) | 27 (29.6%) | 15 (16.4%) |
| Sex, F, n (%) | 29 (58%) | 18 (66.7%) | 10 (66.7%) |
| Age, y | 40 (18–65) | 40 (21–75) | 48 (23–64) |
| EDSS | 3 (0–7) | 2.5 (0–6.5) | 6 (0–7) |
| ARMSS | 6.5 (0.30–9.30) | 4.9 (0.7–8.86) | 8.1 (0.30–9.30) |
| Disease duration, y | 5 (0–32) | 6 (0–28) | 9 (2–40) |
| Total rim lesion volume mm3, n | NA | 6550 | 8115 |
| Total lesion volume mm3, n | 37,279 | 44,307 | 53,593 |
IRL: iron rim lesion positive; EDSS: Expanded Disability Status Scale; ARMSS: Age-related Multiple Sclerosis Severity Score; NA: not applicable.