Table 2.

Clinical outcomes and keystroke dynamics clusters for each clinical visit.

Outcomes		M0	M3	M6	M9	M12
Nine-Hole Peg Testa
	Subjects, n	102	93	76	58	89
	Time (seconds), median (IQR)	21.2 (19.4-25.0)	21.0 (18.7-24.0)	20.5 (18.8-22.5)	20.2 (18.5-22.0)	20.3 (18.7-23.0)
Symbol Digit Modalities Test
	Subjects, n	102	93	76	58	90
	Mean score (SD)	54.4 (10.3)	56.8 (10.4)	57.9 (12.0)	61.3 (12.8)	60.3 (12.9)
Fine motor score cluster
	Subjects, n	96	88	72	55	71
	Time (seconds), mean (SD)	0.45 (0.16)	0.44 (0.16)	0.44 (0.17)	0.39 (0.15)	0.42 (0.17)
	Daysb (n), mean (SD)	14.3 (2.4)	26.4 (4.8)	26.2 (4.8)	25.5 (5.4)	15.5 (5.5)
Cognition score cluster
	Subjects, n	101	89	70	55	72
	Time (seconds), mean (SD)	1.01 (0.42)	0.95 (0.40)	0.92 (0.40)	0.86 (0.38)	0.90 (0.44)
	Daysb (n), mean (SD)	7.8 (1.0)	13.7 (1.0)	13.3 (2.2)	13.1 (2.1)	8.4 (2.7)

^aFor the Nine-Hole Peg Test, an average outlier threshold of 40 seconds was implemented, excluding 14 of 387 samples (3.6%).

^bOnly days with ≥50 keystroke events.