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. 2022 Oct 11;10:988699. doi: 10.3389/fcell.2022.988699

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Copyright © 2022 Monferrer, Dobre, Trujillo, González Oliva, Trubert-Paneli, Acevedo-León, Noguera and Salmeron-Sanchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3D VN hydrogel with tunable stiffness. (A). Comparison between 3 and 10 wt% PEG gel stiffness with/without VN measured using nanoindentation. (B,C). In situ stiffness measurements of 3 (B) and 10 wt% (C) SK-N-BE (2)-loaded hydrogels at 1, 3, and 7 days. A minimum of three maps per replicate were measured and at least two replicates per sample were tested. ANOVA test was used for statistical analyzes.