Table 2. Trends in Hysterectomy-Corrected Cervical Cancer Incidence Rates Among Women 30 to 34 Years Old by Race and Ethnicity, Stage at Diagnosis, and Histology (2012-2019): NPCR and SEER Database.
| Characteristic | Cases, No. (%) | Ratea | APC (95% CI), % | P value | |||
|---|---|---|---|---|---|---|---|
| 2012-2019 | 2012 | 2019 | 2012 | 2019 | |||
| Overall | 8898 (100.0) | 1002 (100.0) | 1241 (100.0) | 10.14 | 11.60 | 2.5 (1.3 to 3.7) | .002 |
| Race and ethnicityb | |||||||
| Hispanic | 1916 (21.5) | 229 (22.9) | 287 (23.1) | 11.72 | 13.69 | 3.0 (0.3 to 5.7) | .04 |
| Non-Hispanic | |||||||
| Black | 1011 (11.4) | 133 (13.3) | 133 (10.7) | 9.72 | 8.79 | −0.8 (−2.8 to 1.2) | .35 |
| White | 5398 (60.7) | 588 (58.7) | 730 (58.8) | 10.28 | 12.08 | 2.8 (0.6 to 5.0) | .02 |
| Other | 573 (6.4) | 52 (5.2) | 91 (7.3) | 6.19 | 9.21 | 5.0 (2.7 to 7.4) | .002 |
| Stage at diagnosis | |||||||
| Localized | 5613 (63.1) | 634 (63.3) | 793 (63.9) | 6.42 | 7.41 | 2.8 (1.3 to 4.3) | .004 |
| Regional | 2393 (26.9) | 264 (26.3) | 333 (26.8) | 2.67 | 3.11 | 1.9 (0.7 to 3.1) | .008 |
| Distant | 539 (6.1) | 67(6.7) | 62 (5.0) | 0.68 | 0.58 | −0.8 (−4.1 to 2.5) | .56 |
| Unknown | 353 (4.0) | 37 (3.7) | 53 (4.3) | 0.37 | 0.50 | 6.8 (0.8 to 13.1) | .03 |
| Histologyc | |||||||
| Squamous cell | 5997 (67.4) | 690 (68.9) | 866 (69.8) | 6.98 | 8.09 | 2.6 (1.0 to 4.2) | .006 |
| Adenocarcinoma | 2362 (26.5) | 254 (25.3) | 313 (25.2) | 2.57 | 2.93 | 3.0 (0.9 to 5.1) | .01 |
| Adenosquamous | 264 (3.0) | 26 (2.6) | 30 (2.4) | 0.26 | 0.28 | −0.5 (−5.7 to 5.0) | .83 |
| Other | 275 (3.1) | 32 (3.2) | 32 (2.6) | 0.32 | 0.30 | −0.7 (−5.4 to 4.3) | .75 |
Abbreviations: APC, annual percentage change; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results.
Rates were calculated as number of cases per 100 000 person-years and age adjusted to the 2000 US population.
Race and ethnicity were categorized as Hispanic, non-Hispanic Black, non-Hispanic White, and other. The other category includes (non-Hispanic) American Indian or Alaska Native, Asian or Pacific Islander, and other unspecified. Race and ethnicity information was abstracted from medical records. Registries use standardized protocol for both race and ethnicity information, initially collected by health care facilities and practitioners.
Human papillomavirus–associated cervical cancers were identified based on the International Classification of Diseases for Oncology, Third Edition site codes C53.0 to C53.9 and histology codes 8010-8671/8940-8941. Histology codes 8050-8084, 8140-8550/8570-8576, and 8560-8563 were used for squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma, respectively. All the other histology codes were considered under other.