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. 2022 Nov 8;13:948335. doi: 10.3389/fimmu.2022.948335

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Copyright © 2022 Garcia-Dominguez, Henry, Ma, Jani, Amato, Manning, Freyn, Davis, Hsiao, Li, Koch, Elbashir, DiPiazza, Carfi, Edwards and Bahl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-PEG Antibody Responses. The mean ± SEM concentrations of (A) anti-PEG IgM and (B) anti-PEG IgG antibodies at Day 56 (before dose 2) are presented by mRNA-1273 dosing interval schedule (prime only or 1-, 2-, 3-, 4-, 6-, and 8-week intervals) with n=8-10 mice per group. Results of corresponding statistical comparisons between groups are shown in Table S8 and Figure S12 . IgG, immunoglobulin G; IgM, immunoglobulin M; mRNA, messenger RNA; PEG, polyethylene glycol; PBS, phosphate-buffered saline; SEM, standard error of the mean.