Table 1:
Baseline characteristics according to PIIINP and to ICTP 1 μg/L interval categories
| Procollagen Type III N- Terminal Propeptide (PIIINP) category | p trend | ||||||
|---|---|---|---|---|---|---|---|
| Minimum - Maximum | 1.32–4.49 | 4.5–5.49 | 5.5–6.49 | 6.5–7.49 | 7.5–8.49 | 8.5–27.71 | |
| Sample size | N=735 | N=1050 | N=721 | N=332 | N=126 | N=107 | |
| Mean (μg/L) | 3.93 | 5.00 | 5.94 | 6.92 | 7.89 | 10.3 | |
| ICTP (μg/L) | 2.8±1.11 | 3.18±1.11 | 3.5±1.47 | 4.03±1.95 | 4.13±2.53 | 5.25±3.8 | <0.0001 |
| Age (years) | 61.7±12.7 | 62.1±13.3 | 62.9±13.3 | 63.9±13.8 | 62.0±12.8 | 63.0±13.2 | 0.006 |
| Male (%) | 44.6 | 50.5 | 49.7 | 49.1 | 46.2 | 52 | 0.53 |
| Height (cm) | 165±12.9 | 166.5±12.9 | 167.1±12.9 | 167.2±13.2 | 166.3±13.6 | 167.1±13.1 | 0.02 |
| Heart rate (beats/min) | 62.6±11.1 | 62.9±12.1 | 63±12.2 | 62.8±12.8 | 64.8±13.7 | 64.6±15.2 | 0.03 |
| Systolic pressure (mmHg) | 125.8±25.6 | 125.7±27.5 | 126.7±27.3 | 129.4±29.3 | 127.8±29.1 | 126±27 | 0.32 |
| Diastolic pressure (mmHg) | 71.8±12.5 | 71.9±12.8 | 72.1±13.1 | 72.7±13 | 73.6±13.9 | 70.8±14.1 | 0.79 |
| Antihypertensive Rx (%) | 29.9 | 31.5 | 33.8 | 39.4 | 46.1 | 38.6 | 0.01 |
| Body Mass Index (kg/m2) | 26.9±6 | 28±6.7 | 28.7±6.9 | 29.7±7.3 | 30.4±7.3 | 30.3±8.8 | <0.0001 |
| Former smoker (%) | 35 | 37 | 38.2 | 36.2 | 39.8 | 38.7 | 0.79 |
| Current smoker (%) | 15.4 | 12.5 | 9.4 | 9 | 9.9 | 12.5 | 0.003 |
| eGFR* <60 ml/min/1.73 m2 (%) | 2.6 | 4 | 5.2 | 8.1 | 8.2 | 10.5 | <0.0001 |
| Collagen Type I Carboxy-Terminal Telopeptide (ICTP) categories | P trend | ||||||
| Minimum - Maximum | 1.12–2.99 | 3–3.99 | 4–4.99 | 5–5.99 | 6–6.98 | 7.01–23.45 | |
| Sample size | N=1329 | N=1080 | N=430 | N=132 | N=45 | N=55 | |
| Mean (μg/L) | 2.44 | 3.45 | 4.4 | 5.41 | 6.43 | 9.55 | |
| PIIINP (μg/L) | 4.95±1.46 | 5.52±1.55 | 6.21±2.55 | 6.57±2.21 | 7.27±2.65 | 7.75±3.18 | <0.0001 |
| Age (years) | 59.9±12.1 | 63.2±13.3 | 65.7±13.4 | 65.9±13.6 | 68.8±12.2 | 70.6±12.6 | <0.0001 |
| Male (%) | 46.1 | 50.4 | 50.7 | 50.8 | 50.7 | 54.3 | 0.07 |
| Height (cm) | 166±13 | 166.6±13 | 166.6±13.4 | 167±12.5 | 168.1±10.9 | 167.4±12.9 | <0.0001 |
| Heart rate (beats/min) | 62.4±11.4 | 63.2±12.3 | 63.5±13 | 64.5±14.3 | 64.1±14.7 | 64.3±13.9 | 0.0002 |
| Systolic pressure (mmHg) | 124.2±26.3 | 127.3±27 | 129.4±27.6 | 125.2±27.2 | 134.8±37.4 | 137.6±32.9 | 0.06 |
| Diastolic pressure (mmHg) | 72.1±13.2 | 72.3±12.5 | 71.7±12.2 | 70.2±13.1 | 71.1±14.1 | 73.4±15.4 | 0.86 |
| Antihypertensive Rx (%) | 27.9 | 32.6 | 42.8 | 50.1 | 46.4 | 60.8 | <0.0001 |
| Body Mass Index (kg/m2) | 27.4±6.4 | 28.5±6.8 | 29.4±7.4 | 30.6±7.8 | 31.4±7.4 | 29.3±7.3 | <0.0001 |
| Former smoker (%) | 36.7 | 36.5 | 37.5 | 37.1 | 41.7 | 38.3 | 0.36 |
| Current smoker (%) | 12.4 | 11.6 | 12.7 | 10 | 11.1 | 11.6 | 0.29 |
| eGFR* <60 ml/min/1.73 m2 (%) | 1.3 | 3 | 10.8 | 10.4 | 19 | 56.6 | <0.0001 |
*
eGFR: Estimated glomerular filtration rate ml/min/1.73 m2 based on CKD-EPI formula using serum creatinine.
Results are given either in percentage (%) or as mean ± standard deviation. Equal concentration interval categories of PIIINP and ICTP were used (note that lowest and highest categories are open-ended).