Table 2.

Mutations hypothesized to cause evolutionary events of loss of the umami taste receptor in Carnivora.

Eventa	Taxon affected	Mutation’s genomic location		Mutationb	Reference
		Gene	Exon
L	Lontra longicaudis	TAS1R1	Exon 1	Homozygous nonsense substitution	Fig. 1A
			Exon 6	1-bp deletion	Fig. 1B
		TAS1R3	Exon 3	1-bp insertion	Fig. 1P
M	Lontra canadensis	TAS1R1	Exon 2	Homozygous nonsense substitution	Fig. 1C
N	Lutra lutra	TAS1R1	Exon 1	1-bp deletion	Fig. 1D; Tarusawa and Matsumura 2020: Fig. S1
		TAS1R3	Exon 1	Start codon homozygous substitution	Fig. 1Q
			Exon 6	1-bp insertion	Fig. 1R
				2-bp deletion	Fig. 1S
O	Amblonyx cinereus	TAS1R1	Exon 2	1-bp deletion	Fig. 1E
		TAS1R3	Exon 1	Homozygous nonsense substitution	Fig. 1T
			Exon 3	Homozygous nonsense substitution	Fig. 1U
P	Aonyx capensis	TAS1R1	Exon 6	4-bp deletion	Tarusawa and Matsumura 2020: Fig. S2
Q	Ailurus fulgens	TAS1R1	Exon 6	1-bp deletion	Fig. 1F; Hu et al. 2017: Fig. 3
R	Phocidae	TAS1R1	Exon 2	41-bp deletion	Wolsan and Sato 2020: mutation U4
			Exon 3	4-bp insertion	Sato and Wolsan 2012: Fig. 1; Wolsan and Sato 2020: mutation U9
		TAS1R3	Exon 3	1-bp deletion	Wolsan and Sato 2020: mutation US11
			Exon 6	1-bp deletion	Wolsan and Sato 2020: mutation US35
				1-bp deletion	Wolsan and Sato 2020: mutation US36
S	Otarioidea	TAS1R1	Exon 2	1-bp deletion	Wolsan and Sato 2020: mutation U2
		TAS1R3	Exon 6	14-bp deletion	Wolsan and Sato 2020: mutation US30
T	Ailuropoda melanoleuca	TAS1R1	Exon 3	2-bp insertion	Li et al. 2010; Zhao et al. 2010; Sato and Wolsan 2012: Fig. 1; Hu et al. 2017: Fig. 3; Wolsan and Sato 2020
			Exon 6	4-bp deletion	Li et al. 2010; Zhao et al. 2010; Hu et al. 2017: Fig. 3; Wolsan and Sato 2020

^aAll events are illustrated in Fig. 3B.

^bMutations within the same exon are listed in order from the 5ʹ to 3ʹ end.