Figure 1.

Response of blood clots to uniaxial strain. (A) Oblique view and close-up top view of clot in between microtensometer grips. One grip is attached to a fixed load cell, and the opposite of the grip is moved by a nanopositioner.(B) Stress-strain response of clots formed by the addition of thrombin to whole blood or clots formed from platelet poor plasma reconstituted with RBCs. (C) Strain energy densities at 50% strain. (D) Stress-strain curves fitted to the nonlinear exponential model σ = 2C₀a₁exp(a₁ε²), where σ is stress, ε is strain, and C₀ and a₁ are model parameters. (E) C₀ and a₁ for untreated and treated clots. Mean ± standard deviation, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.