Figure 6.

Discrete prestressed fiber model predicts the amount of fibrin fiber compacted by contracting platelets. (A and B) Mapping of experimentally determined strain energy density onto model predictions for cross-linked (A) and uncross-linked clots (B). The sets of grayscale lines plot simulated SED as a function of radial compaction strain (horizontal axis) for increasing values of externally applied tensile strain (grayscale bar). The single colored lines (red for untreated and green for T101) show the loci of intersections with experimentally measured SED at each level of applied strain. (C) Correlation between experimentally determined fibrin density on platelet surface and predicted fiber compaction based on area reduction (R² = 0.91). (D) Schematic representation of predicted fiber compaction by platelets. Platelet aggregates sequester fibrin fibers into dense nodes, thereby prestressing the fibers close to platelets.