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. Author manuscript; available in PMC: 2022 Nov 22.
Published in final edited form as: Nature. 2022 Feb 14;603(7903):893–899. doi: 10.1038/s41586-022-04521-7

Figure 1. snRNA-seq profiling of the human cerebrovasculature.

Figure 1.

a. Experimental schematic. b. Global Uniform Manifold Approximation and Projection (UMAP) of 90,970 profiled nuclei from ex vivo human temporal cortex. c. UMAP of 6,847 profiled vascular nuclei from the highlighted cluster in b. d. UMAP of 24,965 in silico sorted vascular nuclei from post mortem human brains. e,f. Highly expressed genes of sub-clusters in c and d, respectively. g. Validation of markers VEGFC, GRM8, and TRPM3 by indirect immunofluorescence staining (each in green pseudocolor). Scale bar, 20μm.