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. Author manuscript; available in PMC: 2022 Nov 22.
Published in final edited form as: Nature. 2022 Feb 14;603(7903):893–899. doi: 10.1038/s41586-022-04521-7

Figure 2. Integrative analysis of human ex vivo, post mortem, and mouse cerebrovascular cell types.

Figure 2.

a-b. UMAP visualization of integrated cells from human ex vivo, human post mortem and mouse, coloring by cell types (a) and data source (b). All vessel-coupled cells were colored in grey. c-f. Differentially expressed genes between human and mouse in endothelial (c, left), pericyte (d, left), smooth muscle cells (e, left), and fibroblast (f, left). X-axis represents the log-transformed fold change and y-axis represents the maximal expression level. The top 20 genes are highlighted in blue for mouse and red for human. Genes that were also cell type markers are bolded. c-f. (right panels), the representative functional enriched terms of human- and mouse-specific/highly expressed genes.