Table 4.

Frequency of Use of Medications in Study Cohorts

Group of Medications	Specialized CoE		National RA Registry		P-value
	(n=7053)		(n=81,386)
	n	%	n	%
NO DMARDs
Non-opioid analgesics (acetaminophen – dipyrone)
Yes	3082	43.7	29,522	36.27	<0.001
No	3971	56.3	51,327	63.07	<0.001
No data	0	0	537	0.66	-
Opioid analgesics (codeine – tramadol)
Yes	1285	18.22	10,217	12.55	<0.001
No	5768	81.78	70,948	87.17	<0.001
No data	0	0	221	0.27	-
NSAIDs
Yes	102	1.45	9499	11.67	0.376
No	6951	98.55	71,530	87.89	<0.001
No data	0	0	357	0.44	-
Corticosteroids
Yes	4234	60.03	39,540	48.583	<0.001
No	2819	39.97	41,265	50.703	<0.001
No data	0	0	581	0.714	-
Calcium
Yes	2969	42.1	35,403	43.5	0.139
No	4084	57.9	45,525	55.94	0.015
No data	0	0	458	0.56
Vitamin D
Yes	2979	42.24	37,557	46.15	<0.001
No	4074	57.76	43,467	53.41	<0.001
No data	0	0	362	0.44	-
Conventional csDMARDs
Azathioprine	87	1.23	898	1.1	0.912
Cyclophosphamide	2	0.03	62	0.08	0.980
Cyclosporine	20	0.28	168	0.21	0.949
Chloroquine	896	12.7	13,107	16.1	0.007
D-penicillamine	3	0.04	16	0.02	0.983
Hydroxychloroquine	82	1.16	1959	2.41	0.465
Leflunomide	2961	41.98	30,229	37.14	<0.001
Methotrexate	4536	64.31	43,073	52.92	<0.001
Sulfasalazine	1249	17.71	9327	11.46	<0.001
Biological DMARDs and small molecules
Abatacept	156	2.21	2465	3.03	0.559
Adalimumab	110	1.56	1384	1.7	0.912
Certolizumab	292	4.14	1759	2.16	0.042
Etanercept	228	3.23	3023	3.71	0.710
Golimumab	123	1.74	889	1.09	0.529
Infliximab	72	1.02	193	0.24	0.399
Rituximab	128	1.81	2170	2.67	0.554
Tofacitinib	80	1.13	1050	1.29	0.902

Note: P value pearson’s chi-square test.

Abbreviations: csDMARDs, conventional Disease Modifying Antirheumatic Drugs; NSAIDs, Non-steroidal anti-inflammatory drugs; RA, rheumatoid arthritis.