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. Author manuscript; available in PMC: 2022 Nov 22.
Published in final edited form as: Nat Biomed Eng. 2022 Jan 10;6(2):129–143. doi: 10.1038/s41551-021-00831-9

Fig. 4 |. A single local dose of anchored IL-12 controls distal, untreated tumours.

Fig. 4 |

a-f, C3H-Hej mice (untreated n = 10 mice/group, IL-12-ABP-p i.t. n=17 mice/group and IL-12-ABP-p + alum i.t. n=15 mice/group) were inoculated subcutaneously (s.c.) with 106 and 0.3×106 Ag104A cells on the right and left flanks, respectively. At day 7, the right flank tumour was treated i.t. with 20 ug IL-12-ABP-p alone or mixed with 100 ug alum. Shown is the experimental setup (a), overall mouse survival (b), and individual tumour growth curves for treated (c, e) and untreated (d, f) tumours. Red arrows indicate timing of i.t. treatments. ABP refers specifically to ABP10. P values were determined by the log-rank (Mantel-Cox) test (b) using GraphPad PRISM.