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. Author manuscript; available in PMC: 2023 Nov 16.
Published in final edited form as: Cell Syst. 2022 Nov 16;13(11):864–873. doi: 10.1016/j.cels.2022.09.006

Figure 2. Schematics of chimeric antigen receptors and receptor logic circuits.

Figure 2.

A. Chimeric antigen receptors are derived from native receptors, exchanging their intracellular domains with extracellular domains to rewire their targeting specificity. B. SUPRA CAR consists of zipFv and zipCAR. Swapping the zipFv allows targeting various antigens by the same zipCAR. C. SynNotch receptor can induce gene expression in response to the desired antigen. Once the antigen is bound to the scFv domain, membrane-bound transcription factor (txn factor) will be released to induce the gene expression. D. Co-LOCKR system consists of a CAR and two adaptor proteins; Cage and Key. Only when Cage and Key are bound on the same target cell, the Cage domain can be exposed to activate the CAR.