Skip to main content
. Author manuscript; available in PMC: 2023 Nov 16.
Published in final edited form as: Cell Syst. 2022 Nov 16;13(11):864–873. doi: 10.1016/j.cels.2022.09.006

Figure 4. Exogeneous cell control with ON- and OFF- switches.

Figure 4.

A. Representative ON-switch incorporating an NS3 protease to control the CAR activity. CAR will be stabilized only under the presence of a drug that can inhibit the protease activity to induce the T cell activation. B. Representative OFF-switch using the zinc finger degron motif and a synthetic ubiquitin ligase. A drug that can induce the dimerization between the degron and the ligase will degrade the CAR, so the T cells cannot be activated under the presence of the drug.