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[Preprint]. 2022 Nov 21:2022.11.17.516888. [Version 2] doi: 10.1101/2022.11.17.516888

Figure 1. Improved detection of infectious Omicron BA.1 in nasopharyngeal swabs using IGROV-1 cells.

Figure 1.

A retrospective series of 135 RT+qPCR+ nasopharyngeal swabs from COVID-19 patients, harboring Delta (n=53) or Omicron BA.1 (n=82) variants was collected. a. Viral RNA loads, measured by RT-qPCR. The samples were ranked from high to low viral RNA load (low to high Ct). b,c. Viral titers were measured in Vero-TMPRSS2 (b) and IGROV-1 cells (c). Delta and Omicron BA.1-positive samples are depicted in the left and right panels, respectively. d. Comparison of infectious titers for Delta and BA.1 samples in IGROV-1 cells (left panel). Black lines represent the median values. e. Percentage of samples harboring detectable infectious Delta (middle panel) or BA.1 virus (right panel) using Vero and IGROV-1 cells. A Chi-square test was performed ****p<0.0001.