Skip to main content
. 2022 Nov 22;17(11):e0276462. doi: 10.1371/journal.pone.0276462

Fig 3. Therapeutic effects of 833&Freso on bleomycin-induced lung infiltration of inflammatory cells detected in BALf.

Fig 3

833c&Freso at the indicated doses (μg/kg) was injected iv into rats on the indicated days after bleomycin challenge (A-D) day 2 (D2), (C-D) day 1 (D1), (C-D) day 1 and 2 (D1&2)). BALf was collected on day 3. Total leukocyte and neutrophil count per ml of BALf (A,C) and percentage inhibition of the bleomycin effect on total leucocyte and neutrophil infiltration (B). Data pooled from 2 independent experiments totaling n = 10 rats per group. (D) Relative inhibition is normalized to single treatment on D2, with n = 5 rats per group. Scatter graphs showing each data point with indicated means ± SD. *P< 0.03, **P< 0.01, and *** P< 0.001 vs. bleo only, by using one-way ANOVA followed by Dunnett’s test, except as indicated otherwise (A and B) when comparing dose differences with Student’s unpaired t test.