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. 2022 Nov 22;11:e78263. doi: 10.7554/eLife.78263

Figure 5. Prospective study of XCI-skew and future cancer diagnosis.

Figure 5.

Using a Cox regression analysis and controlling for age, relatedness and zygosity, XCI-skew is predictive of future cancer incidence in a 10 year follow-up (p=0.012; HR = 1.95). Each cancer event represents the first cancer diagnosis (excluding non-melanoma skin cancer) in each individual. A Kaplan-Meier plot (top) and cumulative events (bottom) of cancer diagnosis in individuals with XCI-skew (N=469) and random XCI (N=948) are shown. 2.9% (28/948) of individuals with random XCI, and 6.4% (30/469) of individuals with XCI-skew, developed cancer in the 10 years follow-up.