Table 1. Histomorphometric analysis of WT and Rspo3+/- females.
| Parameters | 6 wk | 12 wk | 18 wk | Two way ANOVA | |||||
|---|---|---|---|---|---|---|---|---|---|
| WT(n=6) | Rspo3+/-(n=7) | WT(n=4) | Rspo3+/-(n=4) | WT(n=8) | Rspo3+/-(n=6) | Genotype | Age | Interaction | |
| BV/TV (%) | 7.24±0.98 | 8.8±0.88 | 5.84±1.01 | 12.2±0.72*** | 3.28±0.51 | 6.06±1.1* | <0.0001 | <0.0001 | NS |
| Tb.Th (μm) | 28.3±0.91 | 33.6±1.5* | 35.8±2.54 | 40.7±1.31 | 28.2±1.55 | 36.8±2.7** | 0.0003 | 0.0032 | NS |
| Tb.N (/mm) | 2.53±0.27 | 2.6±0.20 | 1.63±0.26 | 3.00±0.15** | 1.13±0.16 | 1.61±0.25 | 0.0025 | <0.0001 | 0.0429 |
| Tb.Sp (μm) | 397±52.6 | 368±26.4 | 618±86.8 | 297±17.1* | 1050±192 | 690±133 | 0.0378 | 0.0008 | NS |
| MAR (μm/day) | 1.4±0.11 | 1.8±0.06 | 1.39±0.17 | 2.5±0.14*** | 1.08±0.15 | 1.5±0.20* | <0.0001 | 0.0016 | NS |
| MS/BS (%) | 22.2±2.06 | 31.4±4.05* | 23.0±3.25 | 27.8±1.63 | 26.8±1.90 | 27.3±1.55 | 0.0394 | NS | NS |
| BFR/BS (μm3/μm2/year) |
116.2±16.6 | 207±30.4** | 116±16.9 | 251±6.43** | 110±17.6 | 153±25.1 | <0.0001 | NS | NS |
| N.Ob/B.Pm (/mm) | 6.72±0.79 | 6.85±0.64 | 3.83±0.45 | 13±1.94**** | 6.60±0.39 | 8.4±0.69 | <0.0001 | NS | 0.0001 |
| Ob.S/B.Pm (%) | 10.3±1.20 | 10.5±1.44 | 4.89±0.38 | 16.3±2.2**** | 9.66±0.52 | 12.3±0.53 | <0.0001 | NS | 0.0007 |
| OS/BS (%) | 4.68±0.78 | 5.51±1.23 | 2.51±0.30 | 9.17±0.77*** | 4.84±0.66 | 8.3±0.74** | <0.0001 | NS | 0.0263 |
| O.Th (μm) | 3.89±0.30 | 4.64±0.37 | 2.76±0.13 | 4.36±0.09* | 2.78±0.37 | 4.24±0.3** | 0.0003 | NS | NS |
| N.Oc/B.Pm (/mm) | 1.08±0.13 | 0.99±0.11 | 3.64±0.31 | 3.67±0.14 | 2.01±0.26 | 2±0.48 | NS | <0.0001 | NS |
| Oc.S/B.Pm (%) | 2.98±0.40 | 3.07±0.37 | 7.89±0.42 | 8.77±0.55 | 5.85±0.86 | 5.7±1.17 | NS | <0.0001 | NS |
| ES/BS (%) | 4.41±1.06 | 4.05±0.42 | 1.67±0.48 | 2.96±0.43 | 6.85±0.82 | 6.74±1.28 | NS | <0.0001 | NS |
Data are expressed as Mean ± SEM. Two way ANOVA followed by Fisher’s LSD post-hoc test. *p<0.05, **=p < 0.005, ***=p < 0.001, ****=p < 0.0001 compared with age-matched WT females.