Figure 14.

Effects of the ERβ inhibitor PHTPP on cerebral infarction volume, cerebral water content, and neurological function in HIBD newborn mice. (a) TTC staining photos of brain tissue sections, n = 6 mice in each group. (b) Quantitative analysis of cerebral infarct volume shown by TTC staining. (c) Quantitative analysis of brain water content in HIBD pups, n = 6 mice in each group. (d) Quantitative analysis of the body weight, (e) righting reflex, (f) negative geotaxis, and (g) grip tests on days 1, 3, 5, and 7 after HIBD induction in neonatal mice, n = 8 mice in each group. ^∗P < 0.05 and ^∗∗∗∗P < 0.0001 compared with the HI + ICA + Vehicle group, NS = no significant difference. Data are presented as the mean ± SDs.