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. 2022 Nov 15;2022:1330928. doi: 10.1155/2022/1330928

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Copyright © 2022 Mengxia Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of the autophagy inhibitor 3-MA on apoptosis-related proteins in HIBD neonatal mice pretreated with ICA. The expression levels of (a) p53, (b) PUMA, (c) Bax, (d) Bcl-2, (e) caspase-3, and (f) cleaved caspase-3 in the cerebral ischemic penumbra (small black box in the upper left brain section) in 3-MA-treated HIBD newborn mice detected by tissue immunofluorescence, n = 8 mice in each group. Bar = 100 μm. (g) Representative western blot images and (h–l) quantitative analysis. (m) Quantitative analysis results of caspase-3 activity detection. ^∗∗∗P < 0.001, and ^∗∗∗∗P < 0.0001 compared to the HI + ICA + Vehicle group. Data are presented as the mean ± SDs, n = 6 mice in each group.