Table 1.

Regulatory role of FXR ligands in NASH

Metabolism	Inflammation	Liver fibrosis
Decrease lipogenesis Decrease gluconeogenesis Increase glucose oxidation Increase glycogen synthesis Increase β oxidation of fatty acids Increase triglyceride clearance	Reduce inflammation Decrease NF-κB Decrease hepatocyte apoptosis	Inhibit hepatic stellate cell activation Reduce collagen deposition