Skip to main content
. 2022 Nov 15;41(7):111651. doi: 10.1016/j.celrep.2022.111651

Figure 4.

Figure 4

Phenotype specialization and temporal regulation of mononuclear phagocytes to placenta microenvironment

(A) UMAP and Leiden re-clustering of MPs. Scaled medians of marker expression show seven subsets. The last three columns show the fraction of each MP subset relative to all MPs across compartments (n = 26 per compartment).

(B) Transformed median intensities across PD-L1+ MP subsets.

(C) UMAPs showing distribution of PD-L1+ MP subsets across compartments.

(D) Transformed PD-L1 median intensity of moDC, patrolling, and phagocytic subsets across compartments.

(E) Linear GEE fitted fractions of moDC, patrolling, and phagocytic MP subsets relative to maternal immune cells across compartments and gestation.

(F) Linear GEE fitted fractions of PD-L1+ MP subsets out of all PDL1+ MPs across compartments and gestation. For (B) and (D), significance is shown as ∗p ≤ 0.05, ∗∗∗p ≤ 0.001 (one-way ANOVA per marker in B and per cell type in D).