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. 2022 Nov 15;41(7):111646. doi: 10.1016/j.celrep.2022.111646

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Accumulation of pTau in oligodendrocytes

(A) Olig2 (magenta) and pTau (AT8, green) from an aged (20-month-old) tg mouse (widefield epifluorescence). Note high density of pTau in fimbria (fi).

(B) Enlarged view of boxed region from (A) of the fornix (fx), showing neuropil threads (axons) and coiled bodies.

(C) Nuclear immunoreactivity for Olig2 (magenta, asterisks) surrounded by coiled bodies (green, AT8). Right, enlarged view of “microcoils” near an Olig2⁺ nucleus (boxed region, middle panel).

(D) Coiled bodies colocalizing with Olig2⁺ nuclei in the fimbria.

(E) AT8⁺ filaments (gold-silver particles) in the cytoplasm of an oligodendrocyte in the ProS next to an Olig2-immunolabeled nucleus (n) (peroxidase labeling) from an aged mouse (case TT21D, 23 months). Right, higher magnification.

Scale bars: 500 μm (A); 100 μm (B); 10 μm (C, left and middle; D); 2 μm (C, right); 1 μm (E, left); 0.5 μm (E, right). Confocal maximum intensity z-projection thickness: 4, 9.6, and 2.4 μm (C); 4 μm (D). AT, anterior thalamus; cc, corpus callosum; st, stria terminalis; Str, dorsal striatum. See also Figure S4.