Figure 4.

Selective impairments in spatial novelty preference

(A) Short-term spatial novelty preference Y-maze test. Left, schematic (extra-maze cues not shown). Novel arm is blocked off for exposure phase and block removed for test phase (magenta bar). Middle, total distance traveled during test phase (p = 0.8712). Right, distribution chart for discrimination ratio; dashed line, no discrimination (0.5, chance; p = 0.0058).

(B) Water escape Y-maze task. Left, schematic: two possible start arms and a goal arm containing a hidden platform submerged in opaque water. Middle, mean values for % correct over time (blocks). Error bars, standard error. Right, distribution chart for probe test (p = 0.5221). Dashed lines, chance.

(C) Non-matching to place T-maze task. Left, schematic: start arm and rewarded goal arms. In choice run, block (magenta bar) is removed. Mean alteration scores over time (blocks) for each age. Error bands, standard error. Dashed line, chance.

(D) Left, distribution chart of mean choice run delay times (ntg, black; tg, green) during training in T-maze at 4 months (p = 0.0218), 7 months (p = 0.0016), and 12 months (p = 0.0145). Right, mean and standard error across blocks. See Figure S5B for forced run delay times.

(E) Elevated plus-maze with open and closed arms (left). Distribution charts for % time in open arms (middle; 3 months, p = 0.0022; 12 months, p = 0.0083) and number of arm entries (right; p = 0.0448).

Asterisks in (A), (D), and (E): significant differences. ntg, non-transgenic; tg, transgenic mice. See also Figure S5.