Table 1.
Baseline patient characteristics by valve type
| SAPIEN 3 (n = 1146) | ACURATE NEO (n = 649) | Evolut R (n = 546) | Evolut Pro (n = 268) | P-value | |
|---|---|---|---|---|---|
| Age (years) | 80.8 ± 6.7 | 82.4 ± 5.4 | 82.1 ± 6.1 | 82.0 ± 5.6 | < 0.001 |
| Male | 663 (57.9%) | 190 (29.3%) | 212 (38.8%) | 104 (38.8%) | < 0.001 |
| Female | 483 (42.1%) | 459 (70.7%) | 334 (61.2%) | 164 (61.2%) | |
| BMI [kg / m2] | 27.0 ± 5.1 | 27.0 ± 4.9 | 26.8 ± 5.2 | 26.5 ± 5.0 | 0.215 |
| Extracardiac arteriopathy | 291 (25.4%) | 128 (19.8%) | 131 (24.0%) | 59 (22.0%) | 0.050 |
| Diabetes | 338 (29.5%) | 192 (29.7%) | 167 (30.6%) | 67 (25.0%) | 0.408 |
| Hypertension | 1018 (88.8%) | 582 (90.0%) | 490 (89.9%) | 229 (85.4%) | 0.208 |
| Coronary artery disease | 725 (63.4%) | 387 (60.1%) | 342 (62.6%) | 152 (56.7%) | 0.166 |
| Previous cardiac surgery | 209 (18.2%) | 73 (11.3%) | 97 (17.8%) | 20 (7.5%) | < 0.001 |
| Renal disease [GFR ≤ 60 ml] | 676 (59.0%) | 373 (57.5%) | 340 (62.3%) | 146 (54.5%) | 0.153 |
| Atrial fibrillation | 429 (38.0%) | 258 (40.2%) | 234 (43.2%) | 83 (31.2%) | 0.008 |
| EuroSCORE II [%] | 3.7 ± 6.6 | 3.4 ± 4.5 | 5.7 ± 6.8 | 4.7 ± 4.3 | < 0.001 |
| Baseline echocardiographic parameters | |||||
| LVEF | < 0.001 | ||||
| > 50% | 708 (62.2%) | 453 (72.4%) | 367 (68.6%) | 195 (73.6%) | |
| 41–50% | 183 (16.1%) | 80 (12.8%) | 71 (13.3%) | 35 (13.2%) | |
| 31–40% | 135 (11.9%) | 63 (10.1%) | 63 (11.8%) | 24 (9.1%) | |
| < 30% | 113 (9.9%) | 30 (4.8%) | 34 (6.4%) | 11 (4.2%) | |
| Mean gradient [mmHg] | 37.7 ± 18.7 | 34.4 ± 19.2 | 34.9 ± 20.7 | 48.1 ± 19.5 | < 0.001 |
| CT Measurements | |||||
| Annulus area [mm2] | 498.7 ± 99.6 | 433.9 ± 75.2 | 452.0 ± 96.4 | 431.2 ± 61.6 | < 0.001 |
| Annulus perimeter [mm2] | 80.4 ± 8.0 | 75.1 ± 6.3 | 76.4 ± 8.1 | 75.0 ± 5.2 | < 0.001 |
| Area derived diameter [mm] | 25.1 ± 2.5 | 23.4 ± 2.0 | 23.8 ± 2.5 | 23.4 ± 1.7 | < 0.001 |
Values are presented as mean ± SD or n (%).
Significant values are presented in bold letters